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Kai, Takeshi; Yokoya, Akinari*; Fujii, Kentaro*; Watanabe, Ritsuko*
Hoshasen Kagaku (Internet), (106), p.21 - 29, 2018/11
It is thought to that the biological effects such as cell death or mutation are induced by complex DNA damage which are formed by several damage sites within a few nm. As the prediction of complex DNA damage at an electron track end, we report our outcomes. These results indicate that DNA damage sites comprising multiple nucleobase lesions with a single strand breaks can be formed by multiple collisions of the electrons within 1 nm. This multiple damage site cannot be processed by base excision repair enzymes. Pre-hydrated electrons can also be produced resulting in an additional base lesion over a few nm from the multi-damage site. This clustered damage site may be finally converted into a double strand break. These DSBs include another base lesion(s) at their termini that escape from the base excision process and which may result in biological effect. Our simulation is useful to reveal phenomena involved in radiation physico-chemistry as well as the DNA damage prediction.
Tada, Junichiro*; Nakashima, Hiroshi; Hayano, Ryugo*; Kobayashi, Hitoshi*; Asano, Yoshihiro*
Wakariyasui Hoshasen Butsurigaku; Kaitei 3-Han, 305 Pages, 2018/03
This book is an introduction to radiation physics. Under the concept of "linking physics of high school and radiation physics" for readers with high school graduation degree, we are doing simple commentary on the basis of qualitative explanation as much as possible. This book begins with "What is Radiation Physics", and consists of 12 chapters, including introductory special relativity, introductory quantum theory, structures of atoms and nuclei, radiations, radioactivity, interactions between radiation and matter, accelerators, radiation dose and so on.
JAERI-M 93-174, 174 Pages, 1993/09
no abstracts in English
JAERI-M 92-124, 204 Pages, 1992/09
no abstracts in English
Kai, Takeshi
no journal, ,
Although many theoretical experimental studies for water radiolysis and its chemical reaction have been performed, the consistency between the physical process and the chemical process has not been maintained. From the current states, we have performed the theoretical studies connected with the physical and the chemical processes. As the results, radiolytic dynamics simulation, which can maintain the consistency, have being developed from the consideration with polarization effects of condensed phase. Thus we proposed a symposium connected with physical and chemical processes, and it was adopted by Japan Physical Society. We show overview of this symposium, and report the forefront of study for the water radiolysis, and the importance of the study connected with physical and chemical processes.
Furuta, Takuya
no journal, ,
Radiation can be defined as electromagnetic waves or particles with high energy that can cause atomic or nuclear reactions. The main types of radiation are photons (X-rays and gamma rays), electrons, protons, heavy ions, and neutrons, but the behavior of various types of radiation within a material differs depending on their interaction with the material. The interaction of various types of radiation is briefly explained, and the results of simulations of the behavior of various types of radiation in matter using the Monte Carlo radiation transport code PHITS are presented. Through the simulation, the lecture will help participants of medical physics background to realize the behavior of various types of radiation.
